Aim To clarify the effects of Angelica on Tnfaip8l2，Ahsg and Tlr3 gene of brain in spontaneously hypertensive rats （SHR）. Methods The SHR were divided into Angelica group and model group，week-old Wistar rats was act as control group. Systolic blood pressure was measured in different groups before and after treatment，after 4 weeks，RNA from brain of mice was extracted and gene expressive profile was measured. Results Angelica can reduce blood pressure levels in SHR. Compared with the model group，Tnfaip8l2,Ahsg and Tlr3 gene in Angelica group were up-regulated in gene expression profile which biology process was all related to inhibition of atherosclerosis. Conclusion Angelica has some function of antihypertensive and can regulate the gene expression profile of brain in SHR. Angelica produce marked effect mainly through inhibiting atherosclerosis.