Aim To investigate the peripheral blood of a disintegrin and metalloprotease with a thrombo spondin type 1 motifs 13（ADAMTS-13）levels in the patient with coronary heart disease （CHD） and its correlation with high-sensitive C-reactive protein （hs-CRP），N-terminal natriuretic peptide precursor （NT-proBNP），high-sensitive cardiac troponin（hs-cTn）. Methods 145 cases of patients who underwent coronary angiography were selected as research subjects. They were divided into three groups by coronary angiography: 47 cases of patients with stable angina as SAP 49 cases of patients with acute coronary syndrome（ACS），including 26 cases of unstable angina（UAP） and 23 cases of acute myocardial infarction（AMI） 49 cases of patients with non-coronary heart disease as control group. The bloods of all patients were collected after inhospital，blood of the AMI group was collected again after 10～14 days as recovery period. The ADAMTS-13 levels of all patients were measured with ELISA. Results The ADAMTS-13 level in the ACS group （286.22±21.75 ng/L） was strikingly lower than that in the SAP group （357.47±21.98 ng/L） and the control group（581.85±21.52 ng/L）,but there was no significant difference between the AMI group （256.21±29.43 ng/L） and UAP group（258.55±31.56 ng/L）. The ADAMTS-13 level in the AMI group after 10～14 days was higher than that in the acute stage （619.91±30.80 ng/L vs 256.21±29.43 ng/L）. In the ACS group，the hs-CRP，NT-proBNP，hs-cTn levels were higher than those in control group and the SAP group the LVEF was lower than that in control group and SAP group. The ADAMTS-13 levels had negative correlation with hs-CRP，NT-proBNP and hs-cTn，but had positive correlation with LVEF. Conclusion The ADAMTS-13 levels had close relation to the stability of coronary heart disease，and the combination with serological markers and LVEF could predict the occurrence of thrombotic events in patients with CHD better.