Aim To expore the correlation between plasma visfatin and coronary atherosclerosis in Kazak and Han patients with coronary heart disease.Methods Forty Kazak and forty-five Han patients with coronary heart disease were picked out randmly as test groups aging from forty to seventy-five, then both test groups were divided into two subgroups (mild sub-group and heavy subgroup) using Gensini score respectively. Thirty-five Kazak and forty Han healthy people were picked out as control groups. Plasma visfatin was measured using enzyme-linked immunosorbent assay (ELISA), meanwhile liver function, renal function, blood lipids, blood glucose and fructosamine were measured.Results Kazak and Han patients with coronary heart disease had higher levels of plasma visfatin than control groups (P<0.01) the heavy subgroup had higher levels of plasma visfatin than the mild subgroup in Kazak and Han patients with coronary heart disease there was a positive correlation between the level of plasma visfatin and Gensini score in the two nationalities ( r0.925 and P<0.01 for Kazak； r0.967 and P<0.01 for Han).Conclusions Kazak and Han patients with coronary heart disease had higher levels of visfatin than their control group. There was a positive correlation between the level of plasma visfatin and Gensini score in the two nationalities, indicating that visfatin might be involved in the occurrence and development of coronary atherosclerosis.