Sphingosine-1-phosphate receptors (S1PR) are important transit point for sphingosine-1-phosphate (S1P) to play roles in cells. Five subtypes of S1PR have been identified so far, which are widely expressed in all systems including cardiovascular system, and play various important biological effects in cardiovascular development, angiogenesis, vasorelaxation, vascular barrier integrity, ischemia/ reperfusion injury and atherosclerosis. This paper makes a review on roles and mechanisms of S1PR in cardiovascular system.