Aim To study the effect of the systematic movement intervention on cardiac function in patients with uremia combined chronic heart failure（CHF）. Method 86 cases of patients with uremia combined chronic heart failure were randomly divided into conventional treatment group and exercise intervention group, which were given equivalent conditions of hemodialysis and foundation treatment. The patients in conventional treatment group avoid any exercise intervention, while in exercise intervention group, the patients were walking at home （or jogging） combined with a resistance movement of exercise intervention, which were observed for 10 weeks. Results In conventional treatment group, the proportion of Class Ⅱ patients based on NYHA heart function classification decreased from 46.51% before treatment to 44.19%, but there was no significant difference（P>0.05）；After exercise treatment, the proportion of Class Ⅱ patients based on NYHA heart function classification increased from 44.19% before treatment to 69.77%, and there was significant difference（P<0.05）；after treatment, there was significant difference of the proportion of Class Ⅱ patients between the two groups（P<0.05）. The level of left ventricular ejection fraction （LVEF） increased from 41.2%±6.5% before treatment to 41.3%±7.1% in conventional treatment group；after ET, the level of LVEF increased from 41.9%±7.0% to 42.9%±6.4%, but LVEF before and after treatment showed no significant difference, and the difference between the two groups after treatment, had no statistical significance（P>0.05）. The levels of the brain natriuretic peptide （BNP） increased from 1120.9±310.6 ng/L to 1143.9±282.3 ng/L after routine treatment, but there was no significant difference（P>0.05）；after ET, the levels of the BNP decreased from 1083.3±294.3 ng/L to 928.8±279.3 ng/L, and there was significant difference（P<0.05） The difference of BNP levels after treatment between the two groups was significant （P<0.01）. Conclusion Exercise intervention of merger of CHF patients with maintenance hemodialysis （MHD） is safe Exercise intervention can improve the merger of CHF patients with MHD NYHA heart function classification, the serum BNP level.