Aim To detect the influence of pretreatment with preoperative low molecular heparin anticoagulation and aspirin antiplatelet on the patients' no-reflow phenomenon and efficacy after interventional therapy of lower limb atherosclerosis occlusion. Methods 126 patients （126 limbs） with lower limb atherosclerosis occlusion undergoing interventional therapy were randomly divided into aspirin group （44 patients） with aspirin for 3～5 days prior to interventional therapy, low molecular heparin group （40 patients） with low molecular heparin for 3～5 days prior to interventional therapy and control group （42 patients） without aspirin and low molecular heparin before interventional therapy. Plasma thrombomodulin（PTM）, soluble fibrin monomer complex（sFMC）, platelet α-granule membrane glycoprotein 140（GMP-140）, D-dimer（DD） and plasma viscosity levels of plasma were measured at four different time points: on admission, before percutaneous transluminal angioplasty（PTA）, immediately after the last PTA and at 24 hours after PTA, while the ankle brachial index （ABI） were detected at two different time points: on admission and at 3 days after PTA. The changes in groups at different time points and the differences between groups at the same time points were compared. The number of postoperative cases of no-reflow occurred limbs, puncture site bleeding or hematoma, acute arterial thrombosis or embolism were recorded at the same time. Results ①In control group, sFMC,GMP-140,DD and plasma viscosity levels was increased （ P<0.05 or 0.01） immediately after the last PTA and rose to peak values, and slightly decreased at 24 hours after PTA, which were still higher than the values before PTA （P<0.05 or 0. 01）. ②Compared with control group, sFMC, GMP-140, DD and plasma viscosity of the two treatments group decreased significantly before PTA（P<0.05）. ③In the two treatment groups,there were no remarkable elevation in the levels of sFMC and plasma viscosity at different time points, compared with the values before PTA （P>0. 05）. However, DD still elevated（P<0.01） compared with the values before PTA, which were much lower than the values at the same time points in control group （P<0.01）.