Aim To analyse the risk factors of patients with carotid intima-media thickness. Methods 1214 patients collected from the ward of cardiology were assigned into two groups according to the IMT thickness by high-frequency ultrasound. IMT≤1.0 mm was classified as normal IMT group, IMT>1.0 mm classified as IMT thickening group. The difference of gender, age, smoking, hypertension, type 2 diabetes, systolic blood pressure, total bilirubin （TBIL）, direct bilirubin （DBIL）, indirect bilirubin （IBIL）, bile acid （TBA）, uric acid （UA）, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein （HDLC）, low density lipoprotein （LDLC）, fasting blood glucose （FBG）, D-dimer between the two groups was compared. Logistic regression analysis was used to analyse the relationship of the IMT and the different factors of the two groups. Results ①The proportion of male, smoking, hypertension, type 2 diabete and the factors of systolic blood pressure, pulse pressure, UA, DBIL, LDLC, FBG, D-dimer of IMT thickening group was higher than the normal group. The age of IMT thickening group was older than the normal group. The TBA of IMT thickening group was lower than the normal group. Those differences were statistically significant（P<0.05）. But the differences of TBIL,IBIL,TG,TC,HDLC between the two groups was not statistically significant（P<0.05）. ②Stepwise Logistic regression analysis showed that smoking, age, LDLC, DBIL, FBG, SBP, D-dimer as the main factors were positively correlated with IMT thickening and its odds ratio （OR）: smoking 2.904（95%CI: 2.050～4.113）, LDLC 1.838 （95%CI：1.534～2.202）, age 1.137（95%CI:1.118～1.157）, FBG 1.072（95%CI:1.008～1.140）, systolic blood pressure 1.011（95%CI:1.005～1.018）, DBIL 1.093（95%CI:1.015～1.176）, D-dimer 1.455（95%CI:1.187～1.785）. Conclusions Smoking, high LDLC, old age, high FBG, elevated systolic blood pressure, high DBIL, high D-dimer are major risk factors for IMT thickening. The foundings have some limitations for cardiovascular patients enrolled,which should be confirmed by multi-center prospective studies.