Based on the theory of aging: nonenzymatic glycosylation,we review the articles about how the reaction of nonenzymatic glycosylation makes effect on blood vessels, causing vascular injury both under physiological and pathological conditions. These works confirm that the process of nonenzymatic glycosylation becomes more serious with increase of age, which can damage blood vessels through many complicated ways and lead to vascular age-related changes in range of form and function. This article tries to discuss the relationship between nonenzymatic glycosylation and vascular aging, aiming to provide the theoretical basis for future research of delaying vascular aging.