Aim To explore the influence factors on atherosclerosis disease of type 2 diabetes mellitus （T2DM）.Methods To investigate 164 cases of type 2 diabetes mellitus resident patients, flow cytometry was used to detect the plasma level of endothelial microparticles （EMP）, ultrasonic was applied to measure the carotid intima-media thickness （IMT） and collect the relevant clinical indexes, risk factors of atherosclerosis in patients with type 2 diabetes were analyzed by multiple factor LR Logistic regression. Results According to the ultrasonic measurement of IMT they were divided into two groups, T2DM with carotid atherosclerosis group （120 cases） T2DM without carotid atherosclerosis group （44 cases）. Compared with T2DM without carotid atherosclerosis group, age was older, duration of diabetes were longer （P<0.01） and EMP, glycosylated hemoglobin A1 （HbA1c）, low density lipoprotein cholesterol （LDLC）, body mass index （BMI） levels were higher in T2DM with carotid atherosclerosis （P<0.05）. Multiple factor LR Logistic showed EMP, LDLC, BMI were independent risk factors of carotid atherosclerosis （EMP OR＝1.382, 95%CI＝1.046～1.826, P＝0.023）. Conclusion EMP, LDLC, BMI were associated with IMT thickening in patients with type 2 diabetes, as the independent risk factors for atherosclerosis, can be used to predict and evaluate the risk of major vascular lesions.