Aim To investigate the alteration of plasma levels of omentin-1, visfatin in old patients with coronary heart disease （CHD） and to explore its clinical significance. Methods Plasma omentin-1, visfatin levels were measured in 90 subjects ［29 stable angina pectoris （SAP） cases, 30 unstable angina pectoris （UAP） cases and 31 age-and sex-matched healthy controls, age≥60years］ using enzyme-linked immunosorbent assay （ELISA） methods. According to the NYHA classification, 59 CHD were divided into three groups: functional Ⅰ class for 11 cases, functional Ⅱ/Ⅲ class for 36 cases, functional Ⅳ class for 12 cases. Results （1）The plasma level of omentin-1 in coronary heart disease patients was significantly lower than that of the control group（717.63±229.11 ng/L vs 1115.49±361.41 ng/L, P＝0.000）, and SAP group’s, UAP group’s were all significantly lower than control group （respectively 780.32±273.19 ng/L vs 1115.49±361.41 ng/L, 652.81±152.94 ng/L vs 1115.49±361.41 ng/L, all P<0.05）. （2）The plasma level of visfatin in CHD patients was significantly higher than the control group （19.22±6.73 μg/L vs 13.31±1.69 μg/L, P＝0.002）, the level of visfatin of SAP group and UAP group were all significantly higher than that of the control group （17.92±4.19 μg/L vs 13.31±1.69 μg/L, 20.43±8.31 μg/L vs 13.31±1.69 μg/L, respective, all P<0.05）. （3）With the increase of NYHA class, the plasma omentin-1 level decreased, while visfatin levels increased gradually, and among the three groups, there were significant differences （omentin-1 respectively 1033.87±277.84 ng/L, 676.58±137.25 ng/L, 540.35±59.49 ng/L, visfatin respectively 13.00±1.19 μg/L, 19.08±2.97 μg/L, 5.23±11.30 μg/L, all P<0.05）. （4）The plasma omentin-1 level was negative correlated with systolic blood pressure （SBP） （r＝－0.264, P<0.05）, positively correlated with high density lipoprotein cholesterol （HDLC） level （r＝0.271, P<0.05）.