Aim To study the effects of three kinds of domestic rapamycin drug-eluting stents（rapamycin drug-eluting stent, biodegradable rapamycin drug-eluting stents and polymer-free rapamycin drug-eluting stent） on serum secretory phospholipase A2 （sPLA2） and high sensitivity C-reactive protein （hs-CRP） levels after stents implantation. Methods 126 patients with unstable angina pectoris （UAP） by angiography were divided into Firebird 2 generation group （33 cases）, Excel group （43 cases） and Nano group （50 cases）, the patients without coronary heart disease （CHD） by coronary angiography during the same period were selected as the control group, serum concentration of sPLA2 and hs-CRP were determined before and at 24 h after coronary intervention. Results Clinical data had no difference in the four groups, and angiography characteristics had no significant differences in the three stent groups （P>0.05）. Serum concentration of sPLA2 and hs-CRP in the three stent groups were significantly higher than those of the control group before and at 24 h after coronary intervention （P<0.01）, but there were no significant differences between the three stent groups. Serum concentration of sPLA2 and hs-CRP at 24 h were significantly higher in each group than those in preoperative （P<0.05）. Compared with preoperative at 24 h, serum concentration of sPLA2 and hs-CRP in the three stent groups were significantly higher than those in the control group （P<0.01）, but there were no significant differences between the three stent groups. Conclusion Three kinds of domestic rapamycin drug-eluting stent implantation can induce the increase of serum sPLA2 and hs-CRP concentrations in short-term, but the inflammatory factor levels had no obvious differences between the three stent groups.