Aim To observe the clinical effect of atorvastatin calcium for the treatment of cerebral atterosclerosis. Methods 226 patients with cerebral arteriosclerosis were chosen as the retrospective analytic object. All cases were divided into the observation group （n121）and the control group （n105） according to treatment regimen. The control group received conventional treatment, and the observation group received additional atorvastatin calcium treatment lipid level, hemorheology, carotid intima-media thickness, plaque area, and the adverse reaction of two groups were comparatively analyzed before and after treatment, then comprehensive evaluation of the clinical effect of different treatment methods was made. Results Lipid level, hemorheology, carotid intima-media thickness of the two groups after treatment had improved,and plaque area decreased, but the control group improved significantly worse than the observation group, and the difference between two groups was significant （P<0.05）； the observation group had a total effective rate of 90.1%, better than the control group 73.3%, which had significant difference （P<0.05）. The adverse reaction rate of control group was 7.6%, observation group was 10.7%, and there was no significant difference between the two groups （P>0.05）. Conclusion On the basis of conventional therapy taking atorvastatin calcium for cerebral atherosclerosis treatment has an obvious effect, and no serious adverse reactions.