Aim To explore the changes and clinical value of cystatin C （CysC） level in gravidas with pregnancy-induced hypertension syndrome（PIH）. Methods 92 cases gravidas with PIH were selected as the observation group, including 34 cases of mild PIH, 31 cases of moderate PIH and 27 cases of severe PIH. 60 cases of normal gravidas were used as control group. The CysC level and serum creatinine （SCr）, blood urea nitrogen （BUN）, uric acid （UA） leve of all gravidas were detected in late pregnancy and postpartum 7 days. Results The cystatin C level in severe PIH gravidas was inscreased significantly compared with the healthy gravidas and mild PIH gravidas and moderate PIH gravidas in late pregnancy （P<0.05）. And more severity of PIH more obvious differences. The SCr,UA and BUN level in severe PIH gravidas were significantly inscreased compared with the healthy gravidas and mild PIH gravidas in late pregnancy （P< 0.05）. The cystatin C level in all gravidas were decreased in postpartum 7 days compared with late pregnancy. The SCr,UA and BUN level were increased in the healthy gravidas and mild PIH gravidas, and the SCr, UA level were decreased in severe PIH gravidas in postpartum 7 days compared with late pregnancy. But the level of CysC and UA were significantly increased in severe PIH gravidas compared with the healthy gravidas and mild PIH gravidas in postpartum 7 days （P<0.01）. Correlation analysis showed the blood pressure related to CysC and UA closely（P<0.01）. Conclusion The CysC level in gravidas with PIH especially in gravidas with severe PIH have obvious change, which combined with other indicators of renal function can sensitively reflect the impairment of renal function and postpartum recovery in gravidas with PIH.