To date, translational medicine is very attractive and multifaceted in the field of science. Aiming at promoting clinical application achievements incrementally, it devotes to break through the inherent barriers between basic research and clinical practice. As well, it plays an important role in bridging the gap between laboratory research and drug development. Herein, we highlight the advances in current ischemic stroke related translational research tragedy, which covers the trends and opportunities in future studies. We also lay emphasis on the necessity of pushing forward stroke-related translational research in an emerging blueprint of neuroscience.