Aim To investigate the effects of angiotensin（1-7）［Ang（1-7）］ and angiotensinⅡ（AngⅡ） on scavenger receptor class B type Ⅰ（SR-BⅠ）, ATP-binding cassette transporter A1（ABCA1） and cholesterol efflux in THP-1 derived foam cells. Methods Human monocytic cell line （THP-1） were induced into macrophages by 100 nmol/L phorbol myristate acetate（PMA） for 48 h, and treated with oxidized low density lipoprotein （ox-LDL） to construct the foam cells, then were randomly allocated into five groups: control group, AngⅡ group,Ang（1-7） group,Ang（1-7）+AngⅡ group and AngⅡ+Ang（1-7）+A-779 group. The mRNA and protein expression of SR-BⅠ, ABCA1 were determined by RT-PCR and Western blot, the intracellular cholesterol efflux rate was detected by liquid scintillator. Results Compared with the control group, AngⅡ decreased SR-BⅠ and ABCA1 in both protein and mRNA, and inhibited the cholesterol efflux（P<0.05）. Those effects could be attenuated by cotreatment with Ang（1-7）（P<0.05）. However when incubated with A-799, an inhibitor of Ang（1-7）, the effects of Ang（1-7） on promoting the expression of SR-BⅠ, ABCA1 and the cholesterol efflux were significantly abolished（P<0.05）. Conclusion In THP-1 derived foam cells, Ang（1-7） via its specific receptor MAS attenuates the reduction of the expression of SR-BⅠ and ABCA1 induced by AngⅡ, and increases the cholesterol efflux.