Aim To investigate the relationship between hepatitis B virus infection and coronary heart disease.Methods 2974 patients according to coronary angiography results were divided into coronary heart disease group and non coronary heart disease group.The relationship between HBsAg positive rate and coronary artery lesion range and the degree was investigated. Results 2974 cases of patients,HBsAg positive rate had statistical significance difference in coronary heart disease group and non coronary heart disease group （P<0.05）.The incidence of coronary heart disease in HBsAg positive people was 1.230 times of HBsAg negative people （OR＝1.230,95%CI＝1.092～1.385,P0.004）.The severity of coronary artery disease,lesion vessels had statistically significant differences in HBsAg positive group and HBsAg negative group （P<0.05）.After adjustment of confounding factors such as systolic pressure,diastolic blood pressure,creatinine,carotid intima-media thickness （IMT） and HBsAg positive,HBsAg positive still was an independent risk factor of coronary heart disease.The risk of coronary heart disease was 1.701 times when HBsAg was positive （OR＝1.701,95%CI＝1.119～2.586,P0.013）. Conclusion There exists correlation between hepatitis B virus infection and coronary heart disease,and the probability of HBsAg positive people suffering from coronary heart disease may increase.