Aim To evaluate the effects on inflammatory factors,lipoprotein（a） in hypertension patients by adding persimmon leaves flavonoid preparation in conventional antihypertensive therapy. Methods According to the inclusion and exclusion criteria strictly,from Jun to Dec 2013,90 hypertensive patients graded 1～2 were included and randomly divided into three groups: persimmon leaves flavonoid preparation group （valsartan and Naoxinqing tablets）,simvastatin group （valsartan and simvastatin）,and control group （valsartan）,30 patients per group.Serum tumor necrosis factor-α （TNF-α）,interleukin-1 （IL-1）,IL-6,IL-8,C-reactive protein （CRP）,endothelin （ET） and lipoprotein（a） ［Lp（a）］ were determined by protein chip method before the therapy and 6 months later. Results After treatment,the inflammatory factors and Lp（a） levels of persimmon leaves flavonoid preparation group and simvastatin group were lower than control group （P<0.01）,but there were no significant differences on inflammatory factors and Lp（a） levels between the persimmon leaves flavonoid preparation group and the simvastatin group （P>0.05）.The blood pressure of patients in control group was significantly reduced after treatment （P<0.05）.The blood pressure of patients with the therapy of persimmon leaves flavonoid preparation and simvastatin decreased more than that of control group （P<0.05）,and low density lipoprotein cholesterol （LDLC） and triglyceride （TG） were reduced （P<0.05）. Conclusions The blood pressure of hypertensives will significantly be depressed after therapy of persimmon leaves flavonoid preparation and simvastatin.In addition,medicine effect of persimmon leaves flavonoid preparation and simvastatin can lead to reduce level of serum inflammatory factors and Lp（a） in hypertension patients.