Aim To probe into the clinical application value of citicoline combined with puerarin treating vascular dementia. Methods From February 2008 to February 2013,112 vascular dementia patients were selected in our hospital.The patients were divided into observation group and control group with randomized block.There were 56 cases in each group.The patients in two groups received clinical drug of citicoline.The patients in observation group received citicoline combined with puerarin treatment.The situation of clinical treatment,HDS score,improved situation of clinical indicators in two groups were compared and analyzed. Results Compared with the patients in control group,the ratios of significant efficiency and overall efficiency for clinical treatment were increased significantly,the ratio of inefficiency was decreased significantly in observation group,there was statistical significance （P<0.05）.Compared with the patients in control group,HDS scores of the patients in observation group after treatment were improved significantly,which were statistically significant （P<0.05）.Compared with the patients in control group,in the patients of observation group after treatment,the mean velocity （VM） and pulsatility index （PI） were improved significantly,which were statistically significant （P<0.05）. Conclusions Citicoline combined with puerarin could promote the overall improvement in the clinical treatment of vascular dementia patients actively in short term.