Aim To establish animal models similar to human disease process of type 2 diabetes mellitus with macroangiopathy . Methods Twenty-four 12 week old Kkay mice with type 2 diabetes mellitus were selected （random blood sugar≥11.1 mmol/L） as model group and twelve C57BL/6J mice as normal control group, experimental animals of the two groups were fed with high sugar and high fat diet, four mice were killed in the model group at the 16 th， 20 th， 24 th and 28 th week. Remaining mice in the model group and normal control group were killed after 28 weeks, and abdominal aorta were observed under light vascular lesions. Results Compared with normal control group, random blood sugar in model group were significantly higher （P<0.01）. Macroangiopathy in the model group was found after 28 weeks, it’s shown as that abdominal aortic endothelial cell structure was not clear, plasma membrane rupture, internal elastic membrane was thin, subendothelial layer thickening, smooth muscle cells and fibroblasts proliferation in great quantities, foam cells cloud be found. Conclusion Kkay mice with type 2 diabetes mellitus by feeding high fat and high sugar after 28 weeks may induce macroangiopathy.