Background In-stent restenosis(ISR)and stent thrombosis(ST)have limited the efficacy of percutaneous coronary intervention(PCI）. Besides technical factors, the inflammatory status of an individual is a strong predictor of the risk of ISR and ST after implantation of drug-eluting stents, the value of these biomarkers remains to be evaluated. Aim We tried to evaluate the change of different inflammatory biomarkers after DES implantation. Methods We selected 130 coronary heart disease(CHD)patients who were implanted DES. The high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)were measured before, 1 day and 3 days after the procedure. Changes of these biomarkers were observed and the relationship with types of CHD and Syntax score were also evaluated. Results The hs-CRP increased significantly at 3 days after PCI compared with baseline(8.12±10.18 mg/L vs. 4.03±5.06 mg/L, P<0.001)and there was a significant increase in the IL-6 level at 1 day after PCI(65.71±34.23 ng/L vs. 56.76±34.08 ng/L, P<0.001）. The level of hs-CRP 1 day(P＝0.002)and 3 days(P＝0.016)after PCI differs between different CHD types, which increased from stable angina pectoris(SAP)to acute coronary syndrome(ACS）. Patients with higher Syntax score got a higher level of hs-CRP at 1 day(7.64±9.82 mg/L vs. 3.60±4.80 mg/L, P＝0.005 )and 3 days(11.13±10.49 vs 5.49±9.20 mg/L, P＝0.002)after PCI. The hs-CRP level at 1 day after PCI was positively correlated with the Syntax score(r＝0.247, P＝0.005）. Conclusions The procedure of PCI in CHD patients will activate acute inflammatory reaction, which can be measured with the change of hs-CRP and IL-6 levels in plasma. The inflammation in ACS patients is stronger than that in SAP patients. Patients with higher Syntax score get higher inflammatory reaction after PCI.