Aim To explore the clinic significance of joint bedside assays of amino-terminal pro-B-type natriuretic peptide(NT-proBNP）, cardiac troponin T(cTnT)and D-dimmer in early phase diagnosis of patients with cardiovascular emergencies. Methods From July in 2012 to December in 2013, we enrolled 257 patients who had clinic signs and symptoms of cardiovascular emergencies in cardiovascular department of our hospital, and they were randomized into regular assay group(n＝126)and quick assay group(n＝131)Moreover, from January to June in 2012 we enrolled 132 patients who had similar clinic signs and symptoms of cardiovascular emergencies and were admitted to hospital in our department as control group. We compared the accuracy rates of admitting diagnosis with discharge diagnosis among control group, regular assay group and quick assay group, and we also compared the 30-days survival rates among the three groups and the joint assay times of NT-proBNP, cTnT, D-dimmer between regular assay group and quick assay group. Results Compared the accuracy rates of admitting diagnosis with discharge diagnosis, the admitting diagnosis accuracy rate was 90.8%, 97.6%, 96.1% in control group, regular assay group and quick assay group respectively. The admitting diagnosis accuracy rates had no significance between the quick assay group and the regular assay group(P>0.05）, and the admitting diagnosis accuracy rates were significantly higher in quick assay group and regular assay group than that in control group respectively(P<0.05）. Moreover, the assay times in quick assay group were significantly shorter than that in regular assay group(P<0.01）. The 30-day survival rates in quick assay group and regular assay group had no significance(P>0.05）, but they were all significantly higher than that in control group(P<0.05）. Conclusion The joint bedside assay of NT-proBNP, cTnT, D-dimmer should be popularized widely for its contributions to quick and accuracy admitting diagnosis and improvement of prognosis in patients with cardiovascular emergencies.