Aim To evaluate the relativity of blood gamma-glutamyl transferase（GGT)level and intracranial and extracranial artery stenosis of cerebral infarction patients. Methods According to computerized tomography angiograph（CTA）, a total of 163 cerebral infarction inpatients were divided into intracranial and extracranial artery with or without stenosis group,the blood GGT levels and other risk factors were compared among groups. Results Artery stenosis groups had significantly higher age, male, smoking, hypertension, diabetes mellitus, triglyceride（TG）, GGT, low density lipoprotein（LDL)levels than those without intracranial and extracranial artery stenosis group（P<0.05）. The levels of blood GGT of pure extracranial artery stenosis group and simple intracranial stenosis group showed no significant difference（P>0.05）. An increase in blood GGT predicts the increasing degree of cranial atherosclerotic stenosis. Logistic regression analysis showed that GGT were indepent risk factors of intracranial and extracranial atherosclerotic stenosis（OR17.863,95%CI:2.583～123.520）,which showed statistic significance（P0.003）. Conclusion The blood level of GGT and cranial atherosclerotic stenosis are closely related. The concentration of GGT is associated with severity of intracranial or extracranial stenosis. GGT is a risk factor for the cranial stenosis and has no selectivity for intracranial or extracranial artery injury.