Hydrogen sulfide （H₂S） is the new gasotransmitter to regulate the function of cardiovascular system after nitric oxide （NO） and carbon monoxide （CO）. H₂S can hinder the development of atherosclerosis by protecting vascular endothelium and inhibiting vascular smooth muscle cell proliferation and foam cell formation. This protective effect of H₂S is achieved through the mechanisms such as anti-inflammation, against oxidative stress. Therefore, hydrogen sulfide is expected as a promising therapeutic target for atherosclerosis.