Aim To explore the prevalence of the cluster of cardiovascular risk factors in the races of the Uygur and the Hans in hospital with insulin resistance（IR） in Urumqi. Methods Oral glucose tolerance test （OGTT） and insulin release test were used to measure concentration of blood glucose and insulin before and after oral 75 g glucose in 0 h,0.5 h,1 h,2 h and 3 h,which were recorded in 219 subjects in hospital. Insulin resistance （HOMA IR） were calculated by Homeostasis model assessment （the Homa model）. Results In the insulin resistance subjects,the Uygur increased significantly in weight and waist-to-hip ratio compared with the controls,whereas the Hans mainly showed the elevated total cholesterol （TC） and low-density lipoprotein cholesterol （LDLC） compared with the controls（P<0.05）. The Uygur increased significantly in weight,body mass index（BMI） and waist circumference compared with the Hans in the insulin resistance subjects（P<0.05）. The Uygur increased significantly in body mass index compared with the Hans,the controls（26.84±4.19 kg/m² vs 25.52±3.19 kg/m²） and the insulin resistance subjects（27.77±3.60 kg/m² vs 26.09±3.68 kg/m² P<0.05）. Diabetes mellitus,hypertension,TC,and triglyceride（TG） had positive correlation with IR（P<0.01） and high density lipoprotein cholesterol（HDLC） had negative correlation with IR by Logistic Regression（P<0.01）. Conclusion The Uygur had more obesity and the Hans had higher cholesterol in the population with insulin resistance in Hospital,Urumqi. Diabetes mellitus,hypertension and dyslipidemia were closely related to IR.