Aim To observe the effect of rosuvastatin on C-reaction protein（CRP）, interleukin-6 （IL-6）, brain natriuretic peptide （BNP）, left ventricular ejection fraction （LVEF）, left atrial diameter （LAD） and sinus rhythm maintenance in patients of the heart failure with paroxysmal atrial fibrillation. Methods All of 98 patients of chronic heart failure （CHF） with paroxysmal atrial fibrillation were converted to sinus rhythm after treatment. They were divided into rosuvastatin group （50 patinets） and control group （48 patinets） on the basis of routine CHF treatment. After follow-up 12 months, the change of CRP, IL-6, BNP, LVEF, LAD, the rate of recurrence of atrial fibrillation, incidence rate of heart failure were compared in two groups before and after treatment and the first and the twelfth month after discharge.