Aim To analyse characateristic of head and neck CTA by 256-slice CT angiography in patients with cerebral infarction of Oxfordshire Community Stroke Project （OCSP） classification,evaluate the relationship between the degree,location of head and neck artery stenosis and the OCSP classification of responsible side in patients with cerebaral infarction. Methods According to the OCSP classification,300 cases of acute cerebral infarction were divided into total anterior circulation infarct （TACI） （37 cases）,partial anterior circulation infarcts （PACI） （109 cases）,posterior circulation infarct （POCI） （66 cases） and lacunar infarct （LACI） （88 cases）,through retrospective analysis of head and neck CTA by 256-slice CT angiography,responsible vessels characteristic were compared in patients of different types. Results The rate of responsible artery stenosis or occlusion was 86.8%,75.3%,88.5% and 86.3% in patients with acute cerebral infarction of TACI,PACI,POCI and LACI subtype.Statistical significance of responsible artery stenosis or occlusion rate between the subtypes was not found（P>0.05）.The degree of head and neck responsible vessels stenosis was different between the OCSP classification.The most of patients of TACI was severe or occlusion,mild or moderate stenosis was dominated in PACI and LACI,mild stenosis was dominated in POCI.The incidence of stenosis or occlusion in TACI was higher than other subtype （P<0.05）.Tandem stenosis or occlusion of intracranial and extracranial artery were dominated in different subtype of OCSP,especially in PACI and POCI（P<0.05）. Conclusion Head and neck responsible vessels stenosis and the degree of stenosis were related to OCSP classification.256-slice CT angiography of head and neck was helpful to determine the cerebrovascular stenosis,the degree of stenosis and the responsibility vessels.