Aim To investigate the role of inflammatory factor and endothelial damage factor in high-salt induced hypertensive rat model. Methods Wistar rats with 8-week old were randomly divided into control group （fed with tap water,n30） and model group （fed with high-salt water containing 2% NaCl,n50）. After fed for 21 days,the blood pressure and hemodynamic parameters were determined. The high-sensitivity C-reactive protein （hs-CRP）,monocyte chemotactic protein-1 （MCP-1）,tumor necrosis factor-α （TNF-α）,interleukin-6 （IL-6）,von Willebrand factor （vWF）,6-keto-prostaglandin （6-K-PG）,endothelial nitric oxide synthase （eNOS）,nitric oxide （NO） and endothelin-1 （ET-1） were detected by the ELISA method. Results After 21 days of high salt dietary,the blood pressure in model group was significantly higher than blank control group. The left ventricular mass index （LVMI） and left ventricular end diastolic pressure （LVEDP） in model group were significantly higher than control group,and the maximal rate of rise and fall of the ventricular pressure （±dp/dt_max） was lower than control group after experiment（P<0.05）. Compared with control group,the hs-CRP,MCP-1,TNF-α and IL-6 in blood plasma were significantly increased in model group,and the levels of the hs-CRP,MCP-1,TNF-α and IL-6 were found to be positively correlated with blood pressure （r0.731,0.583,0.858,0.836,P<0.05）. The vWF and ET-1 were increased and positively correlated with blood pressure too （r0.680,0.739,P<0.05）. The NO,6-K-PG and eNOS were reduced in model group,and the levels of NO,6-K-PG and eNOS were negatively correlated with blood pressure （r－0.710,－0.658,－0.721,P<0.05）. Conclusion After fed with high-salt water for 3 weeks,the blood pressure of model group elevated. There are inflammatory reaction and damage of endothelium in model group.