Aim To observe the influence of atorvastatin on serum level of heart fatty acid binding protein （H-FABP）,oxidized low-density lipoprotein （ox-LDL） in the patients of acute cerebral infarction. Methods Patients were divided into 4 groups: normal blood lipid level group with acute cerebral infarction （CI）,higher blood lipid level group with acute cerebral infarction （CIH）,atorvastatin treatment for acute cerebral infarction （CIT）,atorvastatin treatment for higher blood lipid with acute cerebral infarction （CIHT）. H-FABP and ox-LDL were measured by enzyme linked immunosorbent assay,blood lipid level was measured by biochemistry. Results The serum level of H-FABP was lower in CIHT,CIT groups than that of CIH,CI groups （P<0.05）. The serum level of ox-LDL in CIHT,CIT groups was lower than that of CI and CIH groups （P<0.01）. Conclusions Atorvastatin can decrease the serum level of H-FABP and ox-LDL,and attenuate neurological deficit in the patients of acute cerebral infarction. The hypothesis of atorvastatin neuroprotection was made that atorvastatin may extenuate brain tissue damage and retard oxidation from acute cerebral infarction.