Aim To investigate the prevalence status of hypertension in physical examination population of Guilin and analyze major risk factors of hypertension. Methods 6 660 physical examination people were cross-sectionally investigated by the method of cluster random sampling,mainly including questionnaire investigation,physique measurement and liver color doppler ultrasound examination. Results The crude prevalence of hypertension in the physical examination population was 24.4% （male 27.0% female 21.5%） and the national population rate of being standardized was 20.5% （male standardized rate 22.3% female standardized rate 18.5%）. The prevalence of hypertension increased with age,and the prevalence was obviously higher in male than female before the age of 70（P<0.01 or P<0.05）,while after the age of 70 the prevalence was obviously higher in female than male（P<0.01）. Multivariate logistic regression analysis demonstrated that high age,high BMI,fatty liver,hyperuricemia,high TG,high TC and hyperglycemia were risk factors of hypertension. Conclusions The prevalence of hypertension in physical examination population of Guilin was high in southwestern China. High age,high BMI,fatty liver,hyperuricemia,high TG,high TC and hyperglycemia were risk factors of hypertension.