Recently,exercise-based cardiac rehabilitation has been an important role in preventing and treating cardiovascular diseases. It brings to a great deal of cardiovascular benefit,there is an increasing evidence support that exercise training can promote angiogenesis in coronary heart disease,but the mechanism of angiogenesis is still not fully clarified. Multiple research has proved out that exercise training can increase endothelial progenitor cell （EPC） number and promote EPC’s function to accelerate angiogenesis. At the same time,exercise can also raise the change of microRNA level,while these microRNA may participate in the angiogenesis process. Besides,microRNA level changing may influence EPC function to modulate angiogenesis during physical exercise. This review will focus on discussing the role of exercise training in angiogenesis by EPC and microRNA level,which may provide a new idea to research and treat coronary heart disease.