Aim To investigate the correlation between lipoprotein（a）（Lp（a））,fibrinogen（FIB） and carotid atherosclerosis（CAS） in patients with chronic kidney disease （CKD）. Methods 348 cases of CKD were divided into 4 groups according to the intima-media thickness by carotid ultrasonography, and the normal control group was included in this study. The correlation between Lp （a）, FIB level and the degree of CAS was analysed. Results In patients with CKD, the serum level of Lp（a） and FIB increased gradually with the severity of atherosclerosis, the difference was statistically significant （P<0.01）. Serum Lp（a） and FIB levels were positively correlated with atherosclerosis by Spearson correlation analysis（r0.233,P<0.01r0.315,P<0.01）. Lp（a） and FIB were positively correlated to each other（r0.156，P<0.01）. Both Lp（a） and FIB were associated with CAS by Logistic regression analysis（P<0.05）.