Aim To investigate the effect of ten-eleven translocation oncogene family member 2 （TET2） on oxidized low density lipoprotein （ox-LDL）-treated human umbilical vein endothelial cell （HUVEC） proliferation and migration.Methods HUVEC was incubated with 0, 25, 50, 75 ox-LDL mg/L respectively for 24 h, and Western blot was used to detect HUVEC TET2 protein expression. Methyl thiazolyl tetrazolium （MTT） method was used to detect the effect of TET2 on ox-LDL-treated HUVEC proliferation. Transwell experiment and scratch experiment were used to detect the effect of TET2 intervention on ox-LDL-treated HUVEC migration. Immunofluorescence was used to detect the effect of TET2 intervention on HUVEC cytoskeleton, and Western blot was used to detect the expressions of total Rac1 （tRac1） and phosphorylated Rac1 （pRac1） in HUVEC.Results Oxidized low density lipoprotein inhibited HUVEC TET2 expression with a dose-dependent manner. TET2 overexpression improved the ox-LDL-induced HUVEC proliferation and migration inhibition, while TET2 low expression （TET2 shRNA） further inhibited HUVEC proliferation and migration. Immunofluorescence showed that ox-LDL induced the formation of HUVEC peripheral compact zone. TET2 overexpression inhibited the formation of compact zone induced by ox-LDL, while TET2 shRNA strengthened the compact zone formation. Western blot showed that ox-LDL inhibited the expression of Rac1 protein in HUVEC. TET2 overexpression increased the levels of tRac1 and pRac1 in HUVEC, while TET2 shRNA further decreased the levels of tRac1 and pRac1.Conclusion Oxidized low density lipoprotein can inhibit the expression of TET2, which regulate HUVEC cytoskeleton, so as to inhibit the proliferation and migration of HUVEC.