Atherosclerosis （As） is an important pathological basis of coronary heart disease, cerebral apoplexy disease. In addition to the disorder of lipid metabolism, vascular endothelial injury, oxidative stress and risk factors, many researchers have approved that inflammatory signaling pathway as new risk factors mediated through the formation process of As. Traditional Chinese medicine because of its wide effect, small toxic and side effect, is widely used in the prevention and treatment of As. In this paper, we summarized the action mechanism of inflammatory signaling pathways in As and progress of anti As mechanism of traditional Chinese medicine through intervention in inflammatory signal pathway.