Myocardial fibros is closely related to heart failure, arrhythmias, sudden cardiac death. Prevention and reversal of cardiac fibrosis is one of the key points in clinical research. Pathogenesis of myocardial fibrosis is not fully understood. Currently, it is believed that the development of myocardial fibrosis has close links with inflammatory cells, and autophagy as an important factor in the regulation of inflammatory cell function influences the outcome of myocardial fibrosis. This review elaborates the latest progress of research of inflammatory cells and autophagy of inflammatory cells in myocardial fibrosis.