Aim To evaluate the relationship between visfatin level of peripheral blood and chronic stable coronary artery disease (SCAD). Methods According to the result of coronary angiography and clinical presentation, 76 patients were divided into two groups:chronic SCAD group (n＝54) with significant coronary stenosis and non-CAD group (n＝22) without significant lesions. Serum level of visfatin was measured by enzyme-linked immunosorbent assay (ELISA). The differences of clinical data and serum visfatin level in the two groups were compared. The factors affecting visfatin level were analyzed. The correlation between serum level of visfatin and chronic SCAD was analyzed by Logistic regression model. Results Serum level of visfatin was significantly higher in the chronic SCAD group [2.79 μg/L (2.03 μg/L, 5.08 μg/L)] than that in the non-CAD group [2.54 μg/L (1.48 μg/L, 2.97 μg/L)] (P＝0.040). Multivariate linear regression analysis showed serum visfatin level was affected by high-sensitivity C-reactive protein (hs-CRP) in the chronic SCAD group (β＝0.8,5%CI 0.065-0.308, P＝0.004). Logistic regression analysis revealed that serum visfatin level was an independent risk factor for chronic SCAD (OR 2.6,5%CI 1.046-4.160, P＝0.037).Conclusion Serum visfatin level is significantly elevated in patients with chronic SCAD, which may be closely related to the occurrence of the disease.