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Effect of Insulin on the Expression of MMP9 and TIMP-1 Released from Smooth Muscle Cells and E-selectin Released from Endothelial Cells in SD Rats
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Cardiovascular Internal Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R543.3

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    Abstract:

    Aim To investigate the effect of insulin on expression of MMP-9,TIMP-1 and sES. Methods Primary cultured smooth muscle cells from the internal carotid artery and endothelial cells from the aorta of SD rats treated with different doses of insulin,MMP-9, TIMP-1 and sES released by cells into medium were quantified by ELISA. Results MMP-9 and SES levels were higher in insulin group compared with control group,while TIMP-1 was less than control group(P＜0.05). Significant positive correlation was observed between insulin and MMP-9(r=0.815,P＜0.001)as well as sES(r=0.841,P＜0.001), negative correlation was observed between insulin and TIMP-1(r=-0.740,P＜0.001). Conclusion Insulin augmented the secretion of SES and MMP-9, attenuated the secretion of TIMP-1 in dependence on the concentration.

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GE Chen-Liang, LIU Chang-Hui, TANG Zhen-Wang, WU Jie, SU Hua, WANG Gang, ZHAN Fan, XIE Nan, CHEN Zhong. Effect of Insulin on the Expression of MMP9 and TIMP-1 Released from Smooth Muscle Cells and E-selectin Released from Endothelial Cells in SD Rats[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(2):145-149.

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History
  • Received:August 07,2015
  • Revised:November 10,2015
  • Online: June 30,2016
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