Aim To investigate the effect of H-type hypertension on prognosis of patients with coronary heart disease. Methods From August 2011 to June 3,5 patients with coronary heart disease diagnosed by coronary angiography in our hospital were included in this study. According to whether there were hypertension and hyperhomocysteinemia (HHcy), the patients were divided into H-type hypertension group, hypertension group, HHcy group and control group. All patients were followed up. The clinical data and prognosis of different groups were compared. Results The survival time in H-type hypertension group was significantly lower than that in control group (P＜0.05). Compared with the control group, there was no significant difference in survival time of hypertension group and HHcy group (P＞0.05). After adjusting for various factors such as age, sex, smoking, diabetes, body mass index, blood lipid, creatinine, uric acid, coronary artery lesions, Gensini score and left ventricular ejection fraction, multivariate Cox regression analysis showed that H-type hypertension was an independent risk factor for major adverse cardiac and cerebral event (MACCE) (P＝0.000). After adjusting for other factors, compared with the control group, MACCE risk increased significantly in H-type hypertension group (HR 5.3,5%CI 2.728-9.213), hypertension group (HR 2.9,5%CI 1.226-4.892) and HHcy group (HR 1.8,5%CI 0.910-4.214). MACCE risk was greater in H-type hypertension group. Conclusions Hypertension and high homocysteine have synergistic effects on the poor prognosis of patients with coronary heart disease. We should pay more attention to the screening and management of H-type hypertension in patients with coronary heart disease.