Aim The effects of ghrelin on RAW264.7 derived foam cells migration and its associated mechanisms were investigated. Methods The detection of total cholesterol (TC), free cholesterol (FC), cholesterol ester (CE) and lipid droplets were performed by cholesterol oxides method and oil red O staining, respectively. The effects of ghrelin on RAW264.7 derived foam cells migration were detected by transwell chamber assay, the expression of Akt, p-Akt, cleaved Caspase-3 were semi-quantified by Western blot, the distribution of p-Akt and cleaved Caspase-3 in cells was qualitatively analyzed with fluorescent staining. The dissociation and polymerization of cell cytoskeleton was observed with F-actin fluorescence probe. Results 10-7 mol/L ghrelin could promote the migration of RAW264.7 derived foam cells, which was reversed by LY294002. Western blot analysis showed that 10-7 mol/L ghrelin could significantly increase the expression of p-Akt and reduce the expression of cleaved Caspase-3 (P＜0.05) in RAW264.7 derived foam cells. What’s more, it could improve the ability of RAW264.7 migration obviously (P＜0.05). Interestingly, these processes above can be reversed by LY294002 treatment. Fluorescent analysis demonstrated that there was an obvious expression of Akt in RAW264.7 cells. The treatment of ghrelin could upregulate its expression, while LY294002 treatment downregulated the expression. Conclusion Ghrelin could promote the migration of RAW264.7 derived foam cells, which may be related to the activation of the PI3K/Akt signal pathway.