Aim To investigate the correlation between the levels of PCSK9 and Lp(a) and the severity of coronary artery lesions in patients with coronary heart disease(CHD). Methods 114 CHD patients and 78 healthy subjects were randomly selected to detect the severity of coronary artery lesions through coronary arteriography. We further detected the levels of serum TC, TG, HDLC and LDLC by routine method, and detected the levels of serum PCSK9 and Lp(a) via ELISA. Results The levels of serum TC, LDLC, TG, PCSK9 and Lp(a) in CHD groups were increased compared with control group (P＜0.05). The levels of serum PCSK9 and Lp(a) had positive correlation with Gensini score and severity of coronary artery lesions. In addition, the levels of serum PCSK9 showed a positive correlation with Lp(a), LDLC and TC in CHD groups, but had no significant relation with HDLC, TG, BMI and age. Conclusion PCSK9 levels were positively associated with Lp(a) levels in CHD patients. Moreover, PCSK9 and Lp(a) were positively correlated with the severity of coronary artery lesions.