Aim To investigate the effect and potential mechanism of atorvastatin on the THP-1 macrophage proinflammatory cytokines release induced by lipopolysaccharide (LPS). Methods THP-1 cells were treated with phorbol 12-myristate 13-acetate (100 nmol/L) for 24 h to differentiate into macrophages. The medium was then replaced with serum-free medium containing LPS and (or) atorvastatin. The secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18) were quantitated using enzyme-linked immunosorbent assay analysis. The mRNA level of nucleotide-binding oligomerization domain-like receptor protein 1 (NLRP1) inflammasome was measured by real-time PCR. Western blot was employed to analyze the protein expression of NLRP1 inflammasome. Results Atorvastatin inhibited IL-1β and IL-18 secretion induced by LPS in THP-1 macrophages in a dose- and time-dependent manner. Atorvastatin decreased the mRNA and protein expression of NLRP1 inflammasome in THP-1 macrophages. Conclusion Atorvastatin reduces proinflammatory cytokines release from macrophages, and the mechanism might be related to the inhibition of NLRP1 inflammasome expression.