Aim To investigate the changes and its clinical significance of serum IgG antibodies against malondialdehyde-acetaldehyde adducts in patients with different types of coronary heart disease. Methods 87 patients were divided into four groups according to the clinical condition and coronary angiography results:control group (n＝30), stable angina pectoris group (n＝15), unstable angina pectoris group (n＝12), acute myocardial infarction group (n＝30). Serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts were determined by ELISA. Results The serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts in the stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in the control group (P＜0.05), the serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts in the acute myocardial infarction group and unstable angina pectoris group were significantly higher than those in the stable angina pectoris group (P＜0.05), there was no significant difference between unstable angina pectoris group and acute myocardial infarction group (P＞0.05).Conclusion The serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts were related to the development of coronary heart disease, which had a good predictive effect on coronary heart disease, especially in patients with acute coronary syndrome.