Aim To investigate the relationship between serum ferritin and coronary heart disease (CHD). Methods 256 CHD patients and 256 healthy controls were recruited in our case-control study. Basic information was obtained by using questionnaire and measured for blood pressure, weight, height, waist circumference, hip circumference. Venous blood was collected for detecting serum lipid, fasting plasma glucose and ferritin. All data were analyzed with SPSS 20.0. Multivariate Logistic regression model was used to assess association of serum ferritin with coronary heart disease. Results There was no significant difference for gender and age between patients and controls (P＞0.05). The patients’ body mass index (BMI), ratio of waist to hip circumference, triglyceride, C-reaction protein, serum ferritin, systolic blood pressure, and diastolic blood pressure were significantly higher than that of the controls(P＜0.05). Data from univariate analysis showed that BMI, waist circumference, systolic blood pressure, triglyceride, smoking ,drinking and serum ferritin were risk factors of CHD. The highest group of serum ferritin had a 12.30-fold risk of CHD (95%CI:7.33～20.64) than the lowest group without adjustment for confounding factors. In multivariate Logistic regression model, after adjustment for traditional CHD risk factors, serum ferritin was still associated with CHD. The highest group of serum ferritin had a 13.75-fold risk of CHD (95%CI:8.02～23.56) in model 1, and 7.09-fold risk of CHD(95%CI:3.68～13.64) compared with the lowest group. Conclusion The study confirmed that high serum ferritin was associated with the increased risk of CHD.