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Lecithin-cholesterol Acyltransferase and Atherosclerotic Cardiovascular Disease
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1.Beijing Hospital & Beijing Institute of Geriatrics & Key Laboratory of Geriatrics, Ministry of Health, Beijing 100730, China;2.Clinical Laboratory Center, Ministry of Health, Beijing 100730, China)

Clc Number:

R54

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    Abstract:

    Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme that catalyzes the esterification of free cholesterol in plasma lipoproteins, and plays a critical role in high density lipoprotein (HDL) metabolism and the reverse cholesterol transportation. Although the LCAT study has been carried out for half a century, the relationship between LCAT and atherosclerotic cardiovascular disease is still controversial. In this paper, a review is made on the biochemical characteristics of LCAT, action mechanism of LCAT in lipid metabolism, relationship between LCAT and cardiovascular disease, existence problems in the accurate measurement of LCAT.

    Reference
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ZHANG Li-Jiao, DONG Jun, CHEN Wen-Xiang. Lecithin-cholesterol Acyltransferase and Atherosclerotic Cardiovascular Disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(8):845-849.

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History
  • Received:November 13,2015
  • Revised:February 01,2016
  • Online: July 25,2016
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