Correlation Between Helicobacter Pylori and Plasma Heme Oxygenase-1 and Coronary Heart Disease
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1.Department of Cardiology, ;3.Department of Clinical Laboratory, Mentougou District Hospital of Bejing, Beijing 102300, China;2.Department of Cardiology, Beijing Tiantan Hospital Affilliated to Capital Medical University, Beijing 100050, China)

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R5

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    Abstract:

    Aim To investigate the correlation between helicobacter pylori infection and coronary heart disease as well as heme oxygenase-1 (HO-1). Methods According to the results of coronary angiography, the patients were divided into control group (n=143) and coronary heart disease group (n=149), according to the number of vessels involved, coronary heart disease group was subdivided into one-vessel group (n=38), two-vessel group (n=46), multi-vessel group (n=65). All the patients underwent 13C-breath test, helicobacter pylori antibody and plasma HO-1 determination, at the same time, the patien’s case history was collected, serum uric acid, blood glucose, low density lipoprotein, high sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin were detected. The correlation between helicobacter pylori infection and plasma HO-1 and coronary heart disease were evaluated. Results There were significant difference in smoking, age, low density lipoprotein (LDL), hs-CRP, homocysteine (Hcy) in the two groups. Helicobacter pylori infection and Gensini’s score in coronary heart disease group were significantly higher than those in control group, while plasma HO-1 were significantly lower (P<0.05). Helicobacter pylori infection and Gensini’s score were significantly increased with the number of vessels involved, while plasma HO-1 were significantly decreased with the number of vessels involved (P<0.05). Helicobacter pylori infection was positively correlated with the Gensini’s score (r=0.869, P<0.01), and plasma HO-1 was negatively correlated with the Gensini’s score (r=-0952, P<0.01). Helicobacter pylori infection were negatively correlated with HO-1 (r=-0.858, P<0.01). Conclusion Helicobacter pylori infection and plasma HO-1 have some predictive value to coronary heart disease.

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JING Li-Sheng, WANG De-Zhao, ZOU Ai-Chun, LIU Xiao-Hua, WANG Jun, LI Shi-Jing, WANG Wei-Tao. Correlation Between Helicobacter Pylori and Plasma Heme Oxygenase-1 and Coronary Heart Disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(11):1133-1137.

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History
  • Received:November 03,2015
  • Revised:April 28,2016
  • Adopted:
  • Online: December 02,2016
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