Aim To assess the safety and effect of stent implantation in patients with extracranial cerebral artery stenosis in Xinjiang. Methods From 2009 to 2015, in our hospital, three hundred and twenty-three patients with symptomatic extracranial cerebral artery stenosis underwent carotid artery stenting(CAS)or vertebral artery ostium stenting (VAOS) operation. Their success rate of stent implantation,incidence of perioperative complications,and restenosis during follow-up period, modified Rankin scale(mRS)scores and events at clinical end point were compared and analyzed.Results The success rate of stent implantation in CAS and VAOS was 100％respectively,the incidence of peroperative complications was 14.4％ and 1.2％ respectively,the incidence of events at clinical end point was 15.1% and 12.8%. The incidence of restenosis was 8.8％ and 13.4％ respectively. Cox multivariate regression analysis revealed that male and multiple artery stenosis were the independent risk factors in CAS group( HR=19.249, P=0.02；HR=0.069, P=0.034), and contralateral vertebral artery stenosis was the independent risk factors in VAOS group( HR=0.075, P=0.001). Conclusion CAS and VAOS are safe and effective methods to treat extracranial cerebral artery stenosis, however, we should pay attention to the prevention and treatment of its complications.