Aim To study the effect of urinary protein level on major adverse cardiac and cerebrovascular event (MACCE) and all-cause death in general population cohorts. Methods Prospective cohort study method was used in this study. Health examination data integrity 87292 cases were selected as the research subjects from July 2006 to October 2007 in Kailuan Group. The average age of research subjects was 51.12±12.29 years old. Urine dipstick test was used to detect morning urine. According to the level of urinary protein, population were classified into three groups:urine protein negative group (－), micro-urine protein group (±/＋), and macro-urine protein group (≥2＋). COX proportional hazards model was used to analyze the relationship between urinary protein and MACCE, all-cause death. Results The average follow-up was 6.90±0.72 years. During follow-up there were 3091 cases of MACCE, the cumulative incidence was 5.25/1000 person-year, and there were 4087 cases of all-cause death, the cumulative incidence was 6.84/1000 person-year. The cumulative incidences of MACCE in the three groups were respectively 4.84/1000 person-year, 7.34/1000 person-year, 12.06/1000 person-year. The cumulative incidences of all-cause death in the three groups were respectively 6.10/1000 person-year, 10.28/1000 person-year, 19.30/1000 person-year. The differences among the three groups were statistically significant (P＜0.01). After adjusting for other traditional risk factors, compared with urine protein negative group, RR values of MACCE in micro-urine protein group and macro-urine protein group were respectively 1.24 (95%CI 1.10-1.40) and 1.58 (95%CI 1.38-1.81), and RR values of all-cause death were respectively 1.41 (95%CI 1.27-1.56) and 2.15 (95%CI 1.93-2.39). Conclusion Urine displayed urinary protein is an independent risk factor for MACCE and all-cause death in the general population.