With the accelerated aging of society, the incidence of atherosclerosis(As) is increasing year by year. Now that the initial event of the atherosclerosis is endothelial damage, while lipid metabolism is a major risk factor for vascular injury. But now research shows that some non-lipid material also play an important role in the development of As, such as high homocysteine (HHCy), high blood sugar and high uric acid. These non-lipid factors play a major role in vascular endothelial cells, interference by expression of sticky molecule, changing the state of the pathophysiology of endothelial cells, leading to endothelial damage, contributing to the formation of As lesions. This paper describes some of the mechanisms that the changes of adhesion molecules in non-lipid factors induced atherosclerotic vascular endothelial injury, and describes some of the therapeutic intervention targets expression of adhesion molecules, which has important clinical significance for the treatment of atherosclerosis leading to coronary heart disease, myocardial infarction and other cardiovascular diseases.