Aim To investigate the association between low bone mineral density (BMD) and severity of coronary artery lesion patients with non-diabetic coronary heart disease. Methods A total of 156 patients with non-diabetic coronary heart disease (CHD) with chest pain were enrolled in the study, clinical characteristic of patients was recorded, coronary artery lesion was determined by coronary angiography, the patients were grouped according to the number of coronary artery lesions:non-coronary artery lesion group, single coronary artery lesion group, double coronary artery lesion group, three coronary artery lesion group. Coronary artery clacification (CAC) was evaluated by 64 slice spiral CT, patients were grouped according to coronary artery calcification score:no calcification group (＜10 score), mild calcification group (10～100 score), moderate calcification group (101～400 score), severe calcification group (＞400 score). In addition, the bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (DXA), according to the results, patients were divided into osteoporosis group, osteopenia group and normal bone group, and the difference of the degree of coronary artery lesions between the three groups was compared. Results With the severity of coronary artery calcification and coronary stenosis, the incidence of BMD were increased. The severity of coronary artery calcification and coronary stenosis in osteopenia group and osteoporosis group were significantly higher than that in normal group, there were statistically significant differences among the three groups (P＜0.01). Conclusion Low bone mineral density can be considered as an independent factor of coronary artery calcification and coronary stenosis in coronary heart disease patient without diabetes.