Cholesterol and osteoporosis

Home > Archive>Volume 25, Issue 4, 2017 >422-426

Cholesterol and osteoporosis
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                        ZHANG Jie1ZHANG Jie
Department of Spine Surgery, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
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CAO Qi1CAO Qi
Department of Spine Surgery, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
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TANG Chao-Ke2TANG Chao-Ke
Research Institute of Cardiovascular Disease & Key Laboratory for Atherosclerology of Hunan Province & Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Department of Spine Surgery, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China;2.Research Institute of Cardiovascular Disease & Key Laboratory for Atherosclerology of Hunan Province & Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R363
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Abstract:

Epidemiological studies show that there is a positive correlation between the risk of osteoporosis and the incidence of cardiovascular disease, and hypercholesterolemia plays an important role in the occurrence of osteoporosis. The increase of serum cholesterol and low density lipoprotein cholesterol can lead to the decrease of bone mineral density and the occurrence of osteoporosis. Osteoclast and osteoblast are the main bone metabolism cells to maintain bone homeostasis, and cholesterol plays an important role in bone metabolism. This review summarizes the effects of cholesterol and cholesterol-lowering drugs (statins) on the differentiation, formation and activity of osteoblast and osteoclast, thereby providing a novel strategy for the prevention and treatment of osteoporosis.

Key words:Cholesterol; Osteoporosis; Bone mineral density; Cardiovascular disease

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ZHANG Jie, CAO Qi, TANG Chao-Ke. Cholesterol and osteoporosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(4):422-426.

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Received:December 26,2016
Revised:February 20,2017
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Online: May 18,2017
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