Aim To analyze the clinical features of patients with chronic heart failure (CHF) complicated with renal insufficiency, and to explore the risk factors of CHF with renal insufficiency. Methods 385 cases of CHF patients who were treated in department of cardiology of our hospital were collected, including 211 males and 174 females, with an average age of 69.62±8.59 years. Applying method of retrospective control study, according to estimated glomerular filtration rate (eGFR), the CHF patients were divided into renal insufficiency group [eGFR＜60 mL/(min·1.73 m²)] and non renal insufficiency group [eGFR≥60 mL/(min·1.73 m²)]. The general information, heart basic diseases, concomitant disease, contrast agent application history, echocardiographic parameters, renal function, blood lipids, N-terminal pro-B-type natriuretic peptide (NT-proBNP), D-dimer, hemoglobin, urine microalbumin and other laboratory examination indexes were analyzed and compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of CHF patients with renal insufficiency. Results The incidence of renal insufficiency was about 42.1% in 385 patients with CHF. Univariate analysis showed that the differences of age, NYHA heart function classification, hypertension, anemia, diabetes, atrial fibrillation were statistically significant between renal insufficiency group and non renal insufficiency group (P＜0.05). The levels of serum creatinine, urea nitrogen, uric acid, cystatin C and NT-proBNP in renal insufficiency group were higher than those in non renal insufficiency group, and left ventricular ejection fraction and hemoglobin level were lower than those in non renal insufficiency group (P＜0.05). Multivariate Logistic regression analysis showed that age (OR 1.3,5%CI 1.067-2.231), NYHA heart function classification (OR 1.0,5%CI 1.054-3.212), hypertension (OR 1.7,5%CI 1.175-3.292) and cystatin C (OR 1.9,5%CI 1.027-3.851) were independently associated with renal insufficiency. Conclusion The incidence of renal insufficiency was higher in patients with CHF. The elder age, NYHA heart function Ⅳ classification, hypertension and serum cystatin C were independent risk factors of CHF patients with renal insufficiency.